slaapmiddel doxylamine

Moderators: Team, Superuser, Angela, Sanne

slaapmiddel doxylamine

Berichtdoor Schone slaapster » do 19 jul 2012, 18:40

Ik las dat er in 'slaapsap' ofwel 'Nervensaft' doxylamine zit en dat mensen daar goed op slapen. Ik heb onlangs van een vriendin Unisom 25mg doxylamine uit Amerika gekregen. Ik las ook dat het ook in Spanje te koop is. Is het nog ergens anders te koop?
Schone slaapster
 



Re: slaapmiddel doxylamine

Berichtdoor Dees » do 19 jul 2012, 18:43

Ik weet dat het wérkt. Je moet het niet elke nacht nemen, want dan zal dat wel zijn zoals met alle slaapmiddelen, dat het niet meer werkt. In Frankrijk wordt het in de apotheek verkocht, zonder recept, onder de naam Donormyl, 10 tabletjes van 15 mg en dat kost 2,45.
Groeten, Dees
Gezondheidswetenschapper (Gezondheidsvoorlichting en Geestelijke Gezondheidkunde) * Gewerkt in farmaceutische industrie oncologie o.a. op het gebied van borstkanker * Zelf diagnose borstkanker op 36-jarige leeftijd (2007) * www.caseofdees.wordpress.com
Avatar gebruiker
Dees
Beheerder
 
Berichten: 4467
Geregistreerd: di 15 mei 2012, 08:27


Re: slaapmiddel doxylamine

Berichtdoor Ariane » vr 20 jul 2012, 10:43

Ik kon helaas geen Nederlandse vertaling vinden.

Doxylamine.
From Wikipedia, the free encyclopedia

Doxylamine is one of the many sedating antihistamines used by itself as a short-term sedative, and in combination with other drugs as a night-time cold and allergy relief drug. It is also used in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Indications.

Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power superior to almost every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most effective over-the-counter sedative available in the United States [2] and is more sedating than some prescription hypnotics. One study found that doxylamine succinate was more effective than the barbiturate phenobarbital for use as a sedative.[2]

The dosage required to induce hypnosis (sleep) can be as low as 6.25 mg, but is usually effective in dosages of up to 25 mg. Higher doses are not recommended by the United States Food and Drug Administration, although single dosage recommendations of up to 50 mg are common in some countries, including Australia, where it is marketed under the names Restavit and Dozile. A recent placebo-controlled, double-blind randomized trial found the formulation of doxylamine and pyridoxine marketed as Diclectin to be effective in controlling nausea and vomiting due to pregnancy.[3]

Metabolites.

The two main metabolites are desmethyldoxylamine and didesmethyldoxylamine.

Side effects.

Doxylamine succinate is a potent anticholinergic and has a side-effect profile common to such drugs, including dry mouth, ataxia, urinary retention, drowsiness, memory problems, inability to concentrate, hallucinations, psychosis, and a marked increased sensitivity to external stimuli. Like many hypnotics, it should not be combined with other antihistamines, such as Zyrtec (cetirizine) or Benadryl (diphenhydramine), as this combination can increase the risk of serious side effects. Using doxylamine over a long period of time is not recommended. However, the drug is not addictive and withdrawal effects are unlikely to be experienced with prolonged use.

Toxicity.

Doxylamine succinate is generally safe for administration to healthy adults. Typical preparations that contain doxylamine range from 6.25 mg to 50 mg. The LD50 is estimated to be 50–500 mg/kg in humans.[4] Symptoms of overdose may include dry mouth, dilated pupils, insomnia, night terrors, euphoria, hallucinations, seizures, rhabdomyolysis, and death.[5] Fatalities have been reported from doxylamine overdose. These have been characterized by coma, tonic-clonic seizures and cardiorespiratory arrest. Children appear to be at a high risk for cardiorespiratory arrest. A toxic dose for children of more than 1.8 mg/kg has been reported. A 3 year old child died 18 hours after ingesting 1,000 mg doxylamine succinate.[6] Rarely, an overdose results in rhabdomyolysis and acute renal failure.[7]

Studies of doxylamine's carcinogenicity in mice and rats have produced positive results for both liver and thyroid cancer, especially in the mouse.[8] The carcinogenicity of the drug in humans is not well studied, and the IARC lists the drug as "not classifiable as to its carcinogenicity to humans".[9]

http://en.wikipedia.org/wiki/Doxylamine
Ariane
 


Re: slaapmiddel doxylamine

Berichtdoor Ariane » vr 20 jul 2012, 10:45

Hier kun je het via internet bestellen.

http://www.care4sleep.com/nl/faq/2/wat- ... amine.html
Ariane
 



Keer terug naar Juli 2012

Wie is er online

Gebruikers op dit forum: Geen geregistreerde gebruikers. en 1 gast